4 Curative-intent treatments for early stage HCC include surgical resection, ablation, liver transplantation (LT), and transarterial chemoembolization (TACE). 2, 3 Statistics indicate that the 5-year survival for HCC is 18%, which shows that only 30%вЂ“40% of patients were diagnosed in the early stage.

1 It has been estimated that, in 2018, there were 782,000 deaths and 841,000 new cases of liver cancer in the world, with a higher incidence in men than in women in many parts of the world. Liver cancer, mainly hepatocellular carcinoma (HCC), is the sixth most common cancer type and the fourth deadly cause of cancer in the world. In summary, the current study constructing a ceRNA-based DLEU2L/TAOK1 axis might be a novel important prognostic factor associated with the diagnosis and prognosis of HCC. Furthermore, methylation analyses suggested that the abnormal upregulation of the DLEU2L/TAOK1 axis likely resulted from hypomethylation, and immune infiltration analysis showed that the DLEU2L/TAOK1 axis may have an impact on the changes in the tumor immune microenvironment and the development of HCC. Importantly, we identified the DLEU2L/TAOK1 axis in the ceRNA by using correlation analysis, and it appeared to become a clinical prognostic model by Cox regression analysis. The DLEU2L-hsa-miR-100-5p/ hsa-miR-99a-5p-TAOK1 ceRNA network related to the prognosis of HCC was obtained by performing bioinformatics analysis. The expression profiles of three RNAs (long non-coding RNAs, microRNAs, and mRNAs) were extracted from The Cancer Genome Atlas (TCGA) database. In this study, we aimed to clarify a phosphatase and tensin homolog (PTEN)-related ceRNA regulatory network and identify potential prognostic markers associated with HCC. However, the complexity and behavior characteristics of the ceRNA network in HCC were still unclear.

Increasing evidence has underscored the critical role of the competitive endogenous RNA (ceRNA) regulatory networks among various human cancers. Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to human health.

Feng xing fu zhou